Changes in histone modifications directly affect chromatin packaging and gene expression [ 30].
These modifications can directly affect chromatin packaging as well as influence the binding of chromatin proteins and transcription factors (reviewed in Turner, 2007).
Histone modifications are essential in regulating chromatin packaging and gene expression for proper development and cell function.
Histone modifications are key components of chromatin packaging but whether they constitute a 'code' has been contested.
We report the identification of 36 such genes, which are enriched for functions related to DNA- and chromatin-binding, chromatin packaging and modification, and mRNA export from the nucleus.
These modifications influence gene expression patterns by directly altering chromatin packaging and by generating interactions with chromatin-associated proteins.
Modifications of the N-terminal tails of histone proteins play a crucial role in chromatin packaging and gene expression.
DOI: http://dx.doi.org/10.7554/eLife.05606.002 Post-translational modifications of histones, especially lysine methylation, play important roles in diverse biological processes, such as gene transcription, chromatin packaging, and cellular differentiation.
Orchestrated changes in gene expression take place at the level of chromatin packaging which is regulated by enzymatic activity of epigenetic regulators that in turn affect histone modifications.
We investigated histone modifications, chromatin regulators, TFs, DHSs, and DNA sequence motifs in mESC.
