Sentence examples for modifications chromatin accessibility from inspiring English sources

The latest studies, including many from genome-wide perspectives, have revealed unusual principles of reprogramming for histone modifications, chromatin accessibility, and 3D chromatin architecture.

We then validate those findings with measurements of transcription factor occupancy, histone modifications, chromatin accessibility, and gene expression.

Epigenomic Roadmap project data was used to find enrichment in epigenomic signatures using sequencing technologies that map DNA methylation, histone modifications, chromatin accessibility, and small RNA transcripts (http://www.roadmapepigenomics.org/) [ 32].

First, painstaking technology optimization has made it possible to establish comprehensive epigenomes - comprising DNA methylation and its oxidized variants, multiple histone modifications, chromatin accessibility and the coding and non-coding transcriptome - in limited amounts of primary patient samples; and ongoing efforts could even enable genome-wide DNA methylation analyses in single cells.

Dogan, N. et al. Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Epigenetic variation – polymorphisms at the level of DNA methylation or histone modifications – modulates chromatin accessibility, which can perturb transcriptional activity and spur phenotypic variation.

Together these epigenetic modifications control chromatin accessibility to factors that regulate RNA polymerase II (Pol II) transcription (Additional file 1: Figure S1) [ 21, 22].

The NIH Roadmap Epigenomics Consortium (24) focussed on the mapping of DNA methylation, histone modifications and chromatin accessibility using cell lines and primary human tissues.

The preferential association of NFI with expressed genes prompted us to test whether NFI family members may have the potential to activate gene expression, or whether their binding is rather the consequence of histone modifications and chromatin accessibility at promoters.

N-terminal modifications of histones may change the chromatin accessibility to transcription and they are associated with activation and silencing of the genes [ 6].

For example, gene expression can be regulated at multiple levels that include epigenetic modulation by DNA methylation or through histone modifications that modify chromatin accessibility.