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Such modifications can modulate chromatin structure, and they can be recognized by specific proteins or protein domains.
Histone monoubiquitination together with other types of posttranslational modifications can modulate nucleosome/chromatin structure and DNA accessibility and thus regulate diverse DNA-dependent processes [ 28– 328.
In parallel, we considered the phenomenon of "molecular switches" within allosteric ligands, wherein subtle structural modifications can modulate modes of ligand pharmacology and/or subtype selectivity.
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TGA factors have also been postulated as redox sensors35 because cysteine modification can modulate their binding to NPR1 and to DNA36,37.
Therefore, changes in expression of the tau gene, alternative splicing of its mRNA and its posttranslational modification can modulate the normal architecture and functions of neurons as well as in a situation of tauopathies, such as Alzheimer's disease.
The results show that both gallium and phosphorus modification can modulate the acid property of USY zeolite and weaken the interaction between the active metal and the supports, thus enhancing the degree of sulfidation and the dispersion of Mo species that are beneficial for the HDS of highly refractory organosulfur compounds.
The results suggest that systematic ligand modification can modulate sulfur donor specificity and suggest possible structural features for design of platinum-based bifunctional DNA protein cross-linking agents, rather than the DNA DNA cross-linking principally adopted by the anticancer drug cisplatin and congeners.
This modification can modulate protein function [24].
This indicates that structural changes associated with actin modification can modulate interactions with TM in isoform-dependent manner.
There are over a dozen distinct post-translational modifications that can modulate protein signaling or enzyme activity [ 10].
The N-terminal of core histones protruding from the nucleosome particle is subjected to a variety of post-translational modifications that can modulate gene expression [ 6].
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