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These modifications can alter enzyme activity and may increase the immunogenicity of self antigens, leading to a break in immune tolerance.
Furthermore, post-translational modifications can alter the activity, location, and stability of a protein, and also increase the complexity and dynamics of proteins [36].
As discussed above with respect to DPSL and rubrerythrin, these modifications can alter the charge of a protein, which will shift the position on a 2D gel [73].
PTM is a mechanism for regulating cellular processes; such modifications can alter the strength or number of interactions in which these proteins engage and/or redirect them to sub-cellular compartments as required for proper functioning [1].
Numerous reports have proposed that 5' and 3' modifications can alter miRNA metabolism.
These modifications can alter proteins half-life, increase protein degradation, and decrease cellular functionality (Scharf et al., 2013).
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More recently, it has been shown that P. falciparum AP2 family is subjected to protein acetylation and this modification can alter DNA-binding47, thus adding another layer of complexity on transcriptional regulation in malaria parasites.
In addition to promoter polymorphisms, epigenetic modification can alter downstream gene expression.
This modification can alter the conformation, stability or localization of a protein, consequently regulating its function.
This covalent modification can alter the interactions of restriction enzymes or regulatory proteins with DNA by a direct steric effect.
The new comparative biology lab stream was designed to last four weeks (however, see "Future Prospects and Conclusions" for modifications that can alter this timeline).
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