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Encouragingly, the top two modifications by random forests feature importance, H4K20me3 and H3K9me3, are more frequent in stable nucleosomes containing H2A/H4R3me2s than those containing H2A. Z
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Effect modification by specific-city characteristics, estimated by random effects meta-regression, is shown in Table 1.
In conclusion, it is possible to alter the genome of R. oryzae strains by random mutagenesis and genetic modification.
Modification of existing genes is primarily achieved by random mutations, which occur due to mistakes in DNA replication or mutagenic environmental conditions (Elena and Lenski 2003).
Cellulases are produced industrially using T. reesei strains genetically modified by random mutagenesis or by targeted genetic modifications such as introducing strong inducible promoters, increasing the gene copy numbers or removing undesired secreted proteins [ 15].
RNA was extracted from 5 × 10 cells by the RNAzol™ method, checked for DNA contamination and reverse transcribed by random hexamers as described by the manufacturer with minimal modifications (Rots et al, 2000).
Such modifications can be achieved either by rational redesign, which requires knowledge of the enzyme structure, or by random mutagenesis methods followed by screening.
It's completely by random".
A modification of the Doppler Interferometry Technique is suggested to enable estimating angles of arrival of comparatively broadband HF signals scattered by random irregularities of the ionospheric plasma with the use of small-size weakly directional antennas.
The difficulty in the prediction of post-translational modifications and in phosphorylation prediction in particular, is that short, local sequences even those that match an extremely well defined consensus can occur frequently by random sequence drift.
These random elements are of course caused by random duplication and random inactivation of genes.
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