Sentence examples for modifications by oxidative from inspiring English sources

To investigate involvement of reversible protein modifications by oxidative agents, additional experiments were performed using reducing agent dithiothreitol (DTT) (Sigma-Aldrich, Zwijndrecht, The Netherlands).

In addition to examining the main effect of particulate air pollution on HRV, we also evaluated potential modification by oxidative stress allelic profile, hypertension, obesity and diabetes.

Analysis of mRNA-expression modifications induced by oxidative stress in WT cells revealed 1498 gene regulations (Dataset S1b).

The most protein modification caused by oxidative stress is the carbonyl groups; the most sensitive amino acids are arginine, lysine, proline, threonine, and glutamic acid.

Indeed, severe oxidative stress conditions resulted in a drastic drop in the apoptosis (i.e. GOx 50 mU/ml and 1600 μM), consistent with the notion that pro-oxidant conditions can inactivate caspases by oxidative modification of key cysteine residues, thereby impairing the apoptotic program and promoting a switch to necrosis [ 5].

The modifications of Nm23 caused by oxidative stresses were identified as disulfide crosslinking [20].

This activation appeared not to be mediated by oxidative modifications of the enzyme.

Further, receptor binding seemed to be induced or enhanced by oxidative modifications, aggregation or degradation.

As a consequence, the enzyme becomes irreversibly inactivated by oxidative modifications of both the protein matrix and the prosthetic group.

These authors directly demonstrated that prolonged MV is associated with increased oxidative stress in the diaphragm, as indicated by oxidative modifications to diaphragmatic proteins.

Its activation depends not only on the autophosphorylation of defined tyrosine residues, but is also regulated by oxidative modifications [ 147, 148].