► Histaminylation is a novel posttranslational modification belonging to the class of protein monoaminylations.
The results of this analysis are presented in Table 4 show that the majority of genes subjected to regulatory modifications also belong to most abundant functional categories including genes involved in metabolism, biosynthesis, organism development, cellular organization, translation, transport and stress response.
Dihydrouridine (D) and pseudouridine modification genes belong to dihydrouridine synthase superfamily or pseudouridine synthase superfamily, respectively.
The list of GHCs and their belonging modifications is given in supplementary information (http://www.jaist.ac.jp/~s1060011/SI.zip).ac.jp/~s1060011/SI.zip
Third, this transcriptional pattern predicted a profound effect on the proteome, evident by differences in structure, stability and post-translational modifications of proteins belonging to signaling and metabolic pathways, respectively.
Genes involved in the control of cell cycle, DNA damage response, angiogenesis, cell motility and invasion as well as protein modification and NF-kB signaling belonged to the group of genes downregulated during myogenic differentiation (Table 2).
For each of the 61 significant remodeler-modification pairs, the cohort of independent modification includes genes that belong to the corresponding modification cohort but not any remodeling cohort.
Upon further examination, most of the low-modification-rate libraries belong to hepatitis B virus (HBV) associated samples (including SRX018961, ~62, ~63, ~64 and ~65).
Three unique CDS belonged to the type I restriction-modification system, 3 to the oxidative phosphorylation pathway and 2 as a putative periplasmic protein and a Crp/Fnr family protein, respectively.
As discussed above, the majority of proteins belonging to the differentially upregulated group belonged to proteins of the post-translational modification, protein turnover, and chaperone systems.
