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These comments will be considered for a potential update of the document that will be developed if the evidence base has changed substantially and modifications become necessary.
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Modifications became necessary for the instructions of the individualised dyspnoea items of the CRQ-SA.
Dose modifications became necessary in seven out of 18 patients (39%); in three out of 18 patients (17%) treatment had to be stopped completely.
Since there were multiple ways in which we could combine the different modifications, it became necessary to try to reduce the number of possible network realizations, as outlined in Step III.
Speech and language therapy can provide simple communication aids, as well as assessment of swallowing and advice on dietary modification, and mobility and continence aids often become necessary later in the course.
If the Apollo I disaster experience of 17 years ago provides a model, large-scale modifications will be required and even a total redesign of the shuttle could become necessary.
Integration will become necessary.
Many environmentalists think this will become necessary.
This is when politeness does become necessary.
Now it has become necessary.
"Legal action has regrettably become necessary.
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