Sentence examples for modifications at these from inspiring English sources
The identification and generation of nucleases able to introduce site-specific DNA double-strand breaks, particularly the CRIPSR/Cas system, is a major breakthrough for this field as the endogenous DNA repair machinery can be hijacked to specifically introduce genome modifications at these sites.
Base pairing inhibits chemical modifications at these positions.
Our present study further provides evidence that deficiency of posttranslational modifications at these lysines can disrupt VHL ability to target HIF1α.
LKB1 can be phosphorylated at eight or more different residues, where the modifications at these amino acids have no effect on LKB1 kinase activity [8].
The opposing DNA methylation modifications at these distinct regulatory regions may respectively direct the placement of P1-mm in euchromatin and heterochromatin.
To examine chromatin modifications at these predicted enhancers, we plotted ChIP-Seq reads at the 11,283 CPEs.
Synthetic models that incorporate different axial ligand or distal metal are inspired by the design of heme proteins in nature where these modifications at the heme site are associated with dramatic changes in reactivity.
With the exception of H3K79me3, the location of these modifications at the IRF1 locus is the same as reported in other studies [ 9, 23].
Our data revealed that these modifications at the promoter region were dramatically decreased by knocking down IRF2, while no significant changes were detected at the exon II region of the TLR3 gene.
These modifications at the synaptic level have been observed in various brain regions as well as in neuronal cultures (Carpenter-Hyland and Chandler 2006; Pandey et al. 2008 b ; Roberto et al. 2002; Zhou et al. 2007).
REV1-deficient cells show significantly reduced enrichment of these modifications at the BU-1A promoter but no increase in the H3K9me3 (Fig 7C), a mark characteristic of heterochromatinised loci, consistent with our previous observations (Sarkies et al., 2012).
