Sentence examples for modifications at position from inspiring English sources
However, chemically different modifications at position 34 would expand the ability of a tRNA to read three or even four of the fourfold degenerate codons.
A series of oleanolic acid analogs, characterized by structural modifications at position C-3 and C-28 of oleanane skeleton were synthesized and assessed for antiinflammatory potential towards lipopolysaccharide (LPS) induced nitric oxide (NO) production in macrophages.
Modifications at position 7 were designed to exploit the importance of the hydrogen bond accepting properties of this heteroatom in modulating the adenosine deaminase (ADA) mediated 6-N deamination.
The most potent inhibitors of mycobacteria growth was compound 5 with one electron-neutral 1,2-dicarba-closo-dodecaborane modification at position 1 of thymine, and compound 8 with two modifications, at position 1 and 3.
Interestingly, the (S,S -selective variantS,S -selectiveations at position 114 alone or at residues 114 and 116, whereas the (R,R)-selectivariantsnts are chavecterized by a modificationsosition 80 atone or two mutations at the 80 and 83 positions (Table 2).
These two novel structures clearly suggest that it may be possible for a new substituent to be developed by functional modifications at position of the 4-amino group of oseltamivir in order to make polar contacts with the guanidinium side chain of Arg156, and thereby enhance the binding of a more potent inhibitor.
The most potent TMPKmt inhibitor in the series contained two negatively charged 7,8-dicarba-nido-undecaborate modifications at positions 1 and 3 of thymine (9) and exhibited a Ki value of 1.5 μM.
We recently contributed to this field by a development of novel effective inhibitors of this enzyme by exploring modifications at positions 2 or 15 of estrone (compounds 1, 2 and 3 in this study) [24] and designing fluorine derivatives of estrone [25].
Hence, we hypothesized that polymyxin resistance can be overcome through the introduction of hydrophobic modifications at positions R6 or R7.
The best results were achieved with architectures that involve modifications at positions i and i+4 or i and i+7.
The first group of compounds was designed by cis-Apc substitution of AVP and of some of its analogues having additional modifications at positions 1, 4, and 8.
