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Researchers often track these modifications at multiple levels through survey questions posed to key employees or executives involved in an acquisition.
In order to study the role of NF-Y binding activity in histone modifications at multiple genomic loci, we performed ChIP experiments in proliferating (P) and terminally differentiated (TD) C2C12 skeletal muscle cells.
The epigenetic signature of ES cells is characterized by coexistence of both activating and silencing chromatin modifications at multiple loci.
A subgroup of this family, the JmjC lysine demethylases (JmjC KDMs) are involved in histone modifications at multiple sites.
In the previous analysis we have compared "absolute" levels of histone modifications at multiple classes of loci to discover patterns of co-occurring marks that discriminate among them.
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The biologic relevance of this posttranslational modification at multiple sites in Cx43 is complex, as phosphorylation events are thought to regulate gap junction assembly, disassembly, and channel activity.
Second, Hox genes participate in diverse cell fate determination and reprogramming [ 52, 53], which suggests that Hox-related lncRNAs may mediate genome modification at multiple loci.
A disease outcome likely results from aberrant activity of many different molecular pathways, and thus it is likely that epigenetic modifications occur at multiple genes or genic regions.
Combined, these results are consistent with the highly predictive features identified based on F-scores and suggest that the observed sequence bias for histone modification exists at multiple levels.
The subtelomeres of human chromosome arms 7q and 11q are consisting of a single copy sequence which facilitates a chromosome specific analysis of histone modification levels at multiple loci with increasing distance to the telomere (Fig. 2A).
However, we were only able to achieve partial reduction in ubiquitination, possibly due to modification of TRAF6 at multiple sites.
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