Sentence examples for modifications at gene from inspiring English sources

Differentiation of effector and memory CD8+ T cells is accompanied by extensive changes in the transcriptome and histone modifications at gene promoters; however, the enhancer repertoire and associated gene regulatory networks are poorly defined.

The aim of this study was to investigate the effects of genomic changes in H3K9Ac and H3K9Me2 modifications at gene promoter regions upon human MSC osteogenic differentiation, by employing strategies based on ChIP-on-chip and expression microarray methods.

If HP1a modulates the levels of the PcG/trxG protein modifications at gene promoters, this raises the question of whether the protein is at the promoters.

Briefly, our method clusters genes based on the epigenetic profile of gains (positive difference of normalized levels of ChIP-seq enrichment between the mesenchymal and epithelial states) and losses (negative difference) of histone modifications at gene loci during EMT.

We base the DEPs on scaled differential enrichments (SDEs, see 'Scaled Differential Profiles') for all mapped histone modifications at gene loci, and enhancer associated marks at putative enhancer loci.

Our results further suggest that the alteration of key parameters of the histone code depend upon inhibition of the DNMTs, and DNA hypermethylation mediated by DNMTs may be essential for maintaining a particular combination of histone modifications at gene promoters silenced with aberrant DNA methylation.

Therefore, both nucleosome dynamics as well as local changes in chromatin organization, including introduction and/or removal of covalent DNA and histone modifications, at genes with a key role in cell proliferation, are of primary relevance.

The positioning of histone modifications at genes has been associated with numerous co-transcriptional processes ranging from initiation to elongation to 3' end processing.

These data were used to quantify the differences in enrichment of each histone modification at gene and enhancer loci.

However, the role of histone modification at gene loci that are activated for transcription in response to STAT signaling is poorly defined.

Nutrients, including methyl substrates such as vitamin B6 and folic acid, influence DNA methylation and histone modification at gene promoters and this approach has already been applied to treat autism.