Sentence examples for modifications at both from inspiring English sources
We find that genome-wide DNA demethylation alters occupancy of histone modifications at both promoters and enhancers.
In contrast to most of the previous implementations, which propose changes either in partial product generation or reduction, this work proposes modifications at both partial product generation and reduction stages resulting in an improved performance.
Further work is required to clarify the mechanisms of epigenetic modifications at both COL2A1 and ABCA4, especially during development.
Similar to AT1 cells, MEF26 cells possessed both active and repressive histone modifications at both amplicons 2 and 4 (Fig. 2C, D).
On the basis of these data, we conclude that relatively nonbulky modifications at both N1 and N of dA are sufficient to inhibit pol ν-catalyzed TLS.
The primary screen identified a range of pyrazolo[1,5- a]pyrimidines (series 3, Figure 2) with modifications at both the 3- and 7-positions.
In attempts to prepare more-potent analogues of glycyrrhetinic acid, we synthesized compounds 2– 12, similar to CDDO-Me (1), by introducing modification at both rings A and C (Scheme 1A).
This analysis showed a specific loss of the PcG-linked histone modification at both the neomycin reporter gene and across the endogenous Gata6 locus upon Bcor knockdown (Fig. 4C,D).
We designed and synthesized a series of isoindigo-based derivatives to investigate how chemical structure modification at both the 6,6′ - and 5,5′-positions of the core with electron-rich and electron-poor moieties affect photophysical and redox properties as well as their solid-state organization.
The extension and ligation product is then purified by an exonuclase mixture digestion to remove any DNA fragment with no exonuclease-resistance modification at both ends such as remained primers or probes, primer dimers and genomic DNA, and then amplified using universal NGS PCR primer pairs.
Single cell imaging and genomic analyses have provided consistent evidence on the paucity of several active histone modifications at the nuclear periphery both at the microscopic and the molecular levels in C2C12 myoblasts.
