Sentence examples for modifications are well known from inspiring English sources
Epigenetic modifications are well known to play important roles in disease.
Histone deacetylases (HDACs) are a class of epigenetic modulators with complex functions in histone post-translational modifications and are well known targets for antineoplastic drugs.
Modifications of histone tails are well known and were shown to play an important role in gene regulation.
Among myriad histone modifications, lysine and arginine methylation are well known to influence gene expression globally during development, 83 and it is likely that histone methylation is affected by nutritional status and toxin exposure, just as DNA methylation is affected.
Post-translational protein modifications with SUMO1 and SUMO2/3 are well known to have multiple roles, such as regulating protein activity, stability and/or subcellular localisation, and have also been linked to rDNA maintenance (reviewed in Eckert-Boulet and Lisby (2009) and Geiss-Friedlander and Melchior (2007)).
Two typical epigenetic modifications with great influence on DNA function are well known, DNA methylation and histone modification.
DNA methylation and histone modification signatures, especially those on promoter regions of genes, are well known to be associated with gene expression.
These tragedies are well known.
The candidates are well known.
The issues are well known.
These dens are well known.
