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These modifications are usually the result of workers' activities such as food accumulation and nest construction.
In some older plants, the placement of new shells or topology changes in HENs can be expensive due to various reasons and only minimum topology modifications are usually allowed.
Considering the costs of design modifications are usually very expensive and it may make the product (system) more complex, a novel idea is proposed, which to generate a user manual by analyzing the interaction between product behavior and user behavior during the early design stage to help designer to minimize the possibility of design modification after prototyping phase.
Such phenotypic modifications are usually associated with poor prognosis.
However, these modifications are usually costly and energy-consuming, and the resulting products in large part are characterized by low nutrition value, volatility of the amino acid composition, as well as deficiency in basic amino acids (Coward-Kelly et al. 2006; Staron et al. 2010).
These modifications are usually more prominent in pediatric than adult patients.
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It is therefore often necessary to use eukaryotic expression systems to produce correctly processed proteins, but even then the pattern of modifications is usually different from the natural situation.
However, the organic matters which were used in chemical modification are usually expensive and harmful.
For these latter applications, surface modification is usually necessary to improve wettability, printability and adhesive properties.
The property modification is usually brought about by a change in the microscopic structure of the material.
However, multi-step post-synthesis surface modification is usually required to functionalize as-made NCPs before their biomedical applications.
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