Sentence examples for modifications are typically from inspiring English sources
H3K27me3 modifications are typically present in polycomb-repressed chromatin (Mikkelsen et al. 2007).
Phenotypic modifications are typically introduced at the genomic level through genetic manipulation of the virus producing cells.
Some covalent modifications are typically associated with the same effect on transcription; for example, histone acetylation generally is associated with active gene transcription (Turner 2000).
A cell-based SUMOylation assay was optimized to visualize and quantify SUMO modification, which for endogenous proteins, is a highly dynamic process, and only low levels of modification are typically observed for an individual protein at any given time (Johnson, 2004).
This histone modification is typically associated with gene repression, as is the case for DNA hypermethylation of CpG-island promoters.
The absence of mU (rT) was intriguing, as this modification is typically present as part of the conserved TΨC loop in tRNAs.
Information transmission in cells occurs through complex networks of proteins and genes and is relayed through cascades of biochemical modifications, which are typically studied through ordinary differential equations.
Recently, studies examining the viral genome during the primary HSV-1 infection in vitro have shown that H3 is associated with HSV-1 DNA in the initial stage of the infection, further suggesting that productive HSV-1 infections maintain covalent histone modifications that are typically representative of transcribed cellular genes [5], [13] [17].
What is much more surprising is that the H3K36me and H3K9me3 modifications, which are typically strongly associated with actively expressed and silenced genes respectively, were not correlated with Hairy-induced changes in gene expression in this study.
Measures, such as weight reduction and lifestyle modification, that are typically advocated for obese patients are known to increase plasma adiponectin concentration.
As shown in Figure 3B, values are highest within the transcribed region for the 10 chromatin modifications considered and are typically lowest upstream or downstream of it.
