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These modifications are reversible, but require less reducing power for nitrosylation than for glutathionylation.
Unlike genetic mutations that accumulate in cancer, epigenetic modifications are reversible [20].
It is therefore noteworthy that epigenetic modifications are reversible, which may make them an effective target for therapeutic intervention.
Unlike genetic mutations, epigenetic modifications are reversible, raising the question of whether aging and longevity can be changed if we are able to change the age-associated epigenome.
Epigenetic modifications are reversible nuclear chemical reactions that occur due to the ability of enzymes to exercise opposing catalytic effects (eg, using specific inhibitors).
Since epigenetic modifications are reversible, EpRs can be pharmacologically targeted by small molecule inhibitors, and a rapidly growing number of 'epi-drugs' are receiving FDA approval [ 19].
Similar(45)
The cytoskeletal modifications were reversible upon return to normal growth conditions (1 ×g).
The two groups disagreed about whether the modifications were reversible and which cysteines were required for the modification, and neither group considered the potential role of this protein target in chemoprevention.
Epigenetic modification is reversible and DNA methyltransferase inhibitors may be efficacious in CIMP-positive cancers.
This modification is reversible, allowing for a dynamic measurement of the MAPK activity.
This modification is reversible, and ubiquitinated proteins can be proteolytically deubiquitinated by specific deubiquitinating enzymes [ 30, 31].
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