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These antagonistic modifications within the same promoter region indicate that DNA modifications are restricted to relatively short and specific sequences.
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Strikingly, reorganization of histone posttranslational modifications was restricted to promoters and coding regions of genes belonging to the sterigmatocystin (ST) cluster and did not occur in regions immediately outside of this SM cluster (Reyes-Dominguez et al., 2010).
Similarly, the extent of sandhi modification was restricted in Middle Indo-Aryan.
Medication modification was restricted to second-line drugs for which Bactec MGIT susceptibility was not available.
This broad modification was restricted to H3K9me3 and was not present with H3K27me3 in this region.
This type of modification is restricted to complex type N-glycans.
Yet, if the non-crossover pathway is selected, modification is restricted to a short sequence that undergoes gene conversion.
Whole-genome bisulfite sequencing (BS-seq) of the oyster's mantle tissues revealed that more than 99% methylation modification was restricted to cytosines in CpG context and methylated CpGs accumulated in the bodies of genes that were moderately expressed.
However poly(I C) does not induce any increase in c-IAP2 concentration in two types of non-tumorigenic human cell lines - NP69 and MRC5 - suggesting that this modification is restricted to fully transformed cells.
Finally, the identification of specific post-translational modifications that are restricted to chromatin-bound I κB α converts its modifying enzymes and PS-I κB α in attractive targets for novel therapeutic strategies specific for particular I κB α-associated pathologies and patients.
However, many are restricted to modification of protein termini, via introduction of an N-terminal cysteine and a C-terminal intein, or sortase labelling, which can limit their utility.
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