Sentence examples for modifications are responsible from inspiring English sources

We next set out to determine whether histone modifications are responsible for CDKN1C repression in breast cancer.

Our work [2], [3] and other studies [4], [5], [6] have revealed that epigenetic mechanisms (both DNA methylation and histone modifications) are responsible for silencing cell type-specific transcription factors in pluripotent cells.

Thus, it is likely that alterations of histone modifications are responsible for KRT13 gene repression in OSCC cells.

Whilst various environmental features within the injured tissue are likely to be involved in promoting fibroblast differentiation, it is proposed that stable changes in gene expression due to chromatin modifications are responsible for the sustained myofibroblast phenotype [ 46].

The Aven sequence shows putative O and N glycosylation sites, and it will be interesting to investigate whether such post-translational modifications are responsible for the highest molecular weight forms of the protein.

Thus extracellular vesicles regulate epigenetic processes including DNA methylation, histone modification, and miRNA or lncRNA regulation, and the resultant epigenetic modifications are responsible for changes in the expression of tumor promoting genes and tumor suppressing genes.

During aging, the loss in number of neurons is negligible28, especially compared to the age-accompanying damage of white matter integrity29, which among other modifications is responsible for a decline of large-scale structural networks.

It appears that in situ simultaneous ethoxylation, anionic polymerization of BMI and imide modifications were responsible for creating the new chemical structure and molecular morphology that was different from traditional BMI resins.

Ubiquitination is one of the most common post-translational protein modifications being responsible for proteasomal degradation, membrane transport events, DNA repair and other mechanisms such as signaling and cell cycle control [ 11].

In contrast, deletion of epigenetic modifiers (such as SET1/2 histone methyltransferases and SET3C/RPD3S deacetylases described later) did not affect silencing, showing that nucleosome positioning, but not changes in histone modifications, is responsible for repression.

Changes in DNA methylation and histone modifications have been shown to modulate the expression of several genes in pulmonary fibrosis; however, this is the first demonstration of histone modifications being responsible for the specific downregulation of Fas and the resistance of fibrotic lung fibroblasts to Fas-mediated apoptosis.