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Whether or not these modifications are persistent is an issue to be elucidated in the near future.
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However, because, even after some modification, there was persistent individual item misfit the scale was discarded.
Activity-dependent persistent synaptic modifications are generally thought to be the cellular mechanisms underlying the refinement of neuronal connections in the developing nervous systems [10], [11] and contributing to the processes of learning and memory in the mature brain [12], [13].
Activity-induced persistent synaptic modifications are generally thought to be the cellular mechanism underlying developmental refinement of neuronal connections (Zhang et al. 2001), as well as learning and memory in mature animals (Bliss and Collingridge 1993; Chapman et al. 1999; Martin et al. 2000).
The enzymes that generate persistent methylation patterns and other histone modifications are known as histone code writers.
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