The fact that there is little evidence that underlying DNA has a substantial affect on histone modifications is perhaps unsurprising; patterns and distributions of histone modifications vary between cell types even when from the same genetic background.
The OED notes that the word alcatraz was originally applied to the frigatebird; the modification to albatross was perhaps influenced by Latin albus, meaning "white", in contrast to frigatebirds which are black.
Patients in the Hull Cough Clinic often request advice on lifestyle modification and it was perhaps surprising that these proposals were rejected when offered.
Perhaps these modifications are part of a permissive chromatin environment that facilitates VPA-induced transcription.
Perhaps other modifications are hiding on nucleotides, waiting for their discovery and whatever the case may be, an epic scientific hunt has been launched.
Indeed, this finding is consistent with the observation that post-translational modifications of proteins only rarely contribute to the cognate T cell epitopes bound to class II MHC [15], [16], [17], perhaps because these modifications are removed in lysosomes.
Perhaps heterochromatic histone modifications are more often connected with a multicopy character of the sequences rather than with the expression status (silencing).
Since the Rad60 SLDs interact with components of the SUMO modification machinery [1], it is perhaps not surprising that ubiquitin cannot substitute for either of the SLDs.
Other modifications are more extreme -- the cases are reshaped to look like luggage, perhaps, or wastepaper baskets or alien creatures.
While it is unusual to run this test on discrete data, it is possible (although perhaps poorly motivated in this case), so long as appropriate modifications are made.
