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Therefore tools and methods for targeted genome modifications are of great interest.
While other possible MELD modifications might improve its accuracy in the future [ 12], sodium based MELD modifications are of little prognostic value in the clinical setting of ALF.
Histone modifications are of central importance in the regulation of transcription. 1, 2 Whilst histone acetylation is in general transcriptionally activating, histone lysine methylation can be activating or inhibitory depending on factors including the site and type of modification.
Once loss of bone mass alone is insufficient to cause bone fractures [ 118], it is suggested that other factors, including changes in the bone matrix proteins and their modifications, are of crucial importance to the understanding and prediction of bone fractures [ 119].
Similar(54)
Since no trehalose could be detected in M. tardigradum [19], investigating proteins and posttranslational modifications is of particular importance to clarify surviving mechanisms during desiccation.
Exploring versatile strategies for microstructural evolution and surface modification are of fundamental importance in the development of advanced electrode materials.
*Over 75percentt of genetic modifications are to to increase crop tolerance of herbicides.
Dietary modification is of primary importance in managing cats with chronic renal failure.
The contractive modification is of rational type and includes the nondecreasing function associated with the φ-contractions.
This modification is of great relevance in the regulation of several important processes such as the visual cycle [4], signal transduction [5], and synaptic transmission [6], [7], [8].
These types of modifications are part of future long-term developments of this system.
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