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Epigenetic modifications are modulated in a temporal and spatial manner and act as reversible switches of gene expression that can lock genes into active or repressed states.
The possibility of numerous modifications occurring on a single residue, like the preponderance of lysine PTMs discussed above, raises questions about how these modifications are modulated either temporally or physically to create a functional readout.
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Despite the significant decline in starch concentration following veraison, several genes involved in starch biosynthesis and modification are modulated during ripening [ 40].
Many proteins involved in protein and amino acid metabolism and modification were modulated by both viruses (Table S4).
In vivo, this posttranslational modification is modulated by many kinases and phosphorylated sites are clustered in the accessible head and/or tail domains, probably because of limited kinase access along the coiled coil rod domain [ 22].
Histone tail modifications are dynamic processes that are modulated by other protein complexes and noncoding RNAs, such as small RNAs.
These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications.
Understanding the mechanisms of prenatal maternal effects in birds requires analysing the "natural" modifications of yolk hormonal components, which are modulated by females.
The functions of ECM glycoproteins are modulated by posttranslational modifications, such as glycosylation, phosphorylation and sulfation.
Catalytic activities are modulated by component modification and system parameters and are often dependent upon driving forces for intramolecular electron transfer, reductive excited state quenching, and component modification.
The binding of MOZ/MORF complexes to specific genomic regions and their activity are modulated by posttranslational histone modifications.
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