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These modifications are mediated by small RNAs that are localized in CBs (scaRNAs) [14], [27] [30].
Arginine modifications are mediated by two classes of protein arginine methyltransferases (PRMTs), class I and II.
These modifications are mediated by multi-step enzymatic reactions involving an activating (E1), conjugating (E2), and ligase (E3) enzyme that function consecutively to selectively transfer the PTM to substrates [1].
Epigenetic modifications are mediated by methylation, deacetylation, ubiquitination, phosphorylation and microRNA.
Histone modifications are mediated by several protein complexes, which target specific sequences through interactions with gene promoters and transcription factors [ 119, 120].
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The link between DNA methylation and histone modifications is mediated by a group of proteins with methyl-CpG-binding activity.
These T cells recognize better gluten peptides that are deamidated, and this posttranslational modification is mediated by the enzyme transglutaminase 2 (TG2).
This post-translational modification is mediated by a family of three HIF-1α prolyl hydroxylases that use oxygen as a substrate such that enzymatic activity is tightly regulated by oxygen concentration.
Target site modification is mediated by erythromycin resistance methylase (erm) genes.
We also conducted planned secondary analyses of whether effect modification was mediated by digoxin dose or by serum digoxin concentration.
This latter modification is mediated by ShhC, which shows similarity to intein domains and catalyses its own cleavage to form N-palmitoylated/ O-cholesterylated ShhN (19 kDa) (Fig. 1).
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modifications are coordinated
modifications are correlated
modifications are regulated
modifications are facilitated
alterations are mediated
changes are mediated
modifications are initiated
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modifications are attenuated
modifications are outlined
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modifications are described
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