Sentence examples for modifications are implicated from inspiring English sources

Carcinogen-induced DNA modifications are implicated as a major mechanism of altered gene activation in neoplasia, leading to phenotypical alterations.

Over the last decade the implication of epigenetic pathways in BC tumorigenesis has emerged: cancer-related epigenetic modifications are implicated in both gene expression regulation, and chromosomal instability.

The emergent interest in cancer epigenetics stems from the fact that epigenetic modifications are implicated in virtually every step of tumorigenesis.

Epigenetic mechanisms including chromatin rearrangements by DNA methylation and histone modifications are implicated in mammalian development and are characteristic of differentiation of ESCs toward somatic cells.

Advanced glycation end products (AGEs) are formed when glucose reacts nonenzymatically with proteins; these modifications are implicated in aging and pathogenesis of many age-related diseases including type II diabetes, atherosclerosis, and neurodegenerative disorders.

This developmental pathway is best understood at the level of transcriptional regulation where important signaling molecules, transcription factors, and epigenetic modifications are implicated in lineage commitment, cell survival, and establishment of synaptic connections.

Epigenetic gene regulation, such as DNA methylation and histone modifications, is implicated in lineage specification and maintenance.

Protein glycosylation, as an important post-translational modification, is implicated in a number of ailments.

Aberrant O-GlcNAc modification is implicated in human diabetes, and age related neurodegenerative diseases [ 5- 7].

Oxidative stress resulting from an oxidant/antioxidant imbalance in favor of oxidants causes biological modifications that are implicated in several pathological conditions, including respiratory diseases that may be caused and/or aggravated by the exposure to air pollution and cigarette smoke.

Histaminylation is thus a member of a larger family of previously neglected posttranslational protein modifications (monoaminylations) that are implicated in mammalian signaling, whose spectra of biological function needs now to be defined [40].