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In somatic lineages, modifications are generally stably maintained and are characteristic of different specialized tissues.
To achieve low power implementation of DSP circuits, pipelining, parallel processing, algebraic transformations, and algorithmic modifications are generally employed [10].
Activity-dependent persistent synaptic modifications are generally thought to be the cellular mechanisms underlying the refinement of neuronal connections in the developing nervous systems [10], [11] and contributing to the processes of learning and memory in the mature brain [12], [13].
As Abu-Farah and colleagues found histone methyltransferase activity to be essential for target gene upregulation [32], we also determined the extent of H3K4 as well as H3K36 methylation in neonatal Smyd2 cKO versus control hearts, as these histone modifications are generally believed to be associated with actively transcribed genes [30] [31], [48] [49].
Although histone modifications are generally recognized as epigenetic modifications, not all histone modifications are heritable [ 29].
Several other modifications coexist with these marks over different domains [ 4], but these modifications are generally less characterised.
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An underrelaxation of the current profile modifications is generally needed for stable iteration of the algorithm.
The free energy of binding for the combined two modifications was generally found to be additive, demonstrating the predictive value of earlier libraries.
A weaker enrichment of transcription-associated histone modifications was generally observed around HIV insertion sites, with the exception of those extending throughout the body of active genes (H4K12ac, H2BK5me1, H3K27me1, H3K36me3, and H4K20me1).
In contrast, nucleosome occupancy and the same histone modifications were generally depleted in introns.
In the 9-month-old samples, the percentages of previously stated modifications were generally lower (Fig. 4b,c).
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