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The conditions and the nature of such modifications are defined and examined.
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Toxicity and dose modifications were defined by the same protocol whether in-patient or outpatient.
Electrocardiogram (ECG) modifications were defined as ST changes or T-wave inversion.
It is clear that systolic BP levels of 130 139 mmHg or diastolic BP levels of 80 89 mmHg that are considered prehypertension in the general population, and require only lifestyle modification, are defined as hypertension that requires drug treatment in patients with type 2 diabetes and in subjects with metabolic syndrome.
In this study, regimen modification was defined as any changes in antiretroviral drugs (including single substitutions).
Treatment modification was defined as any change of one or more cART components excluding dosage adjustments.
A site modification is defined by a sequence of alphanumeric symbols.
cART modification was defined as any change of at least 1 antiretroviral during the first year of treatment.
Effect modification is defined as a significant interaction (p < 0.10) between group allocation and the variable in question.
Here, co-modification was defined as the Pearson correlation coefficient between gene modifications across gene pairs within the group, and we used a bootstrap analysis to compute it.
Effect modification was defined as a significant (p < 0.10) interaction term between the group allocation variable and the variable of interest.
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