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Over 1000 kinds of modifications are currently available in the database.
Other immunological modifications are currently tested to abolish the alpha-gal burden.
Associations of specific DNA binding proteins with histone modifications are currently studied by chromatin immunoprecipitation followed by sequencing (Chip-Seq).
Treatments to reverse the aberrant epigenetic modifications are currently under intensive preclinical and clinical investigations and are discussed below.
Epigenetic modifications are currently considered as fundamental hallmarks of human cancer, playing a pivotal role in tumorigenesis [ 97].
The mechanisms underlying the observed differential effects on histone post-translational modifications are currently unknown and deserve investigation.
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The development of these modifications is currently under way, and the second run of the experiment commenced in July 2008.
This 'activation' of RNA Pol II is linked to the degradation of maternal PIE-1, but the connection between loss of PIE-1, the transient appearance of the RNA Pol II phosphoepitopes, and the erasure of chromatin modifications is currently unclear.
In particular their optical properties that can be easily tuned by either variation of particle size and composition and/or subsequent surface modification are currently comprehensively studied.
Further studies showed an important role of MUT68 in miRNA and siRNA degradation through its 3′ uridylation activity [ 73]. 3′ uridylation of piRNAs have been observed in zebrafish and drosophila, but the enzymes responsible for this modification are currently unknown [ 12, 17].
Further structural modification is currently underway basing on the primary SAR to discover the potential nicotinamides containing 1,3,4-oxadiazole.
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