Moreover, Stat3 and c-Myc co-occupancy with pluripotency-related genes and regions of active histone modifications is correlated with target gene activity, while Stat3 co-occupancy with polycomb repressive complex proteins (PcG), or regions with repressive bivalent histone modifications (H3K4/27me3) is correlated with target gene inactivity in ES cells.
Furthermore, we found that co-occupancy of Stat3 and c-Myc target genes with pluripotency-related TFs and regions of active histone modificiations is correlated with gene activity, while Stat3 co-occupancy with polycomb repressive proteins and regions of repressive histone modifications is correlated with gene inactivity (Figure 8A C).
As for tumour recurrence, histone modifications were correlated with local recurrence with H3K27me3 P=0.0011) and H3K9Ac (P=0.084) but not with distant recurrence with H3K27me3 P=0.1722) and H3K9Ac (P=0.291).
These results demonstrate that mitochondrial genome modification is correlated with an absolute increase in both synonymous and nonsynonymous substitution rates for mitochondrial protein-coding genes, independent of phylogeny (fig. 2).
They include acetylation, methylation, phosphorylation, ubiquitination and other modifications and are correlated with chromatin accessibility and transcriptional activity or repression [ 6, 7].
Numerous studies have identified several patterns of post-translational modifications that are correlated with specific gene expression activities, but an understanding of the biochemical mechanisms that give rise to these preferred states is lacking (3).
We show enhancer histone modification states are correlated with the expression of nearby genes.
Complementary analyses of samples with Fourier transform infrared spectroscopy suggest that modifications in fluorescence are correlated with photo-oxidative degradation of ABS.
The shell was central for rapid evolutionary success of molluscs, and shell modification and divergence are correlated with adaptive radiations during this early period.
Modifications of the landscape are correlated with intervals of rapid climate change recorded in globally distributed multiproxy data sets.
