Sentence examples for modifications are central from inspiring English sources

Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated is a matter of continued debate.

Post-translational modifications are central modifiers of protein activity [20], [21].

Covalent histone modifications are central to all DNA-dependent processes.

DOI: http://dx.doi.org/10.7554/eLife.01632.002 Histone modifications are central to the regulation of all chromatin-based processes.

The structural mechanisms underlying specific recognition of histone tail sequences and post-translational modifications are central to the emerging concept of chromatin as a complex signaling platform where diverse epigenetic marks can make or break circuits in a synergistic or antagonistic manner (Fischle et al., 2003a, b; Garske et al., 2010; Latham and Dent, 2007).

The measurement of these phenotypical and functional DC modifications was central to the development of several in vitro test protocols for the detection of sensitizers [12], [13], [14].

An altered pattern of epigenetic modifications is central to many common human diseases, including cancer 41 (box 4).

The superfamily includes enzymes involved in bacterial lipopolysaccharide/teichoic acid formation and eukaryotic N-linked glycosylation, modifications that are central in many biological processes.

The key regions in an siRNA duplex for such modifications are the central position, the seed region and the 3'-end of the sense-strand siRNA element, which appear to be related to target RNA cleavage, target RNA recognition and assembly of the antisense-strand (guide) siRNA element into RISCs, respectively.

Such modifications are often central to a protein's function.

Histone modifications are of central importance in the regulation of transcription. 1, 2 Whilst histone acetylation is in general transcriptionally activating, histone lysine methylation can be activating or inhibitory depending on factors including the site and type of modification.