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Exact(7)
Immunogenicity, difficult synthesis, and scale-up of these modifications are all engineering obstacles that stand in the way of expanding the use of these therapeutics.
Moreover, the "modifications" are all rather radical.
These modifications are all synonymous substitutions occurring only at nucleotide level (as specified in the Methods ).
This seems counterintuitive as the examined histone modifications are all associated with gene activity, and so, their loss should have adverse effects on gene expression and tumour growth.
With the possible exception of acetylation, which has not been sufficiently characterised, PCNA modifications are all associated with DNA-bound PCNA.
These four modifications are all strongly correlated with each other within pericentromeric regions indicating that they are likely to be found on the same nucleosomes.
Similar(53)
Generally, food modification is all about selfish pursuits like molecular gastronomy or the global food crisis, but not always.
Expression of the LASS4, PTGES, ZDHHC1 and ZDHHC8 transcripts involved in lipid biosynthesis, metabolism and modification were all increased.
Technological enhancement and body modification surgeries are all the rage in the burgeoning criminal class.
Smaller class size, a classroom aide, setting specific goals for his students and modifications for standardized tests are all mandated to help him teach and his students learn.
The modifications to the car are all sensible, but Ferrari do need to go again.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com