Some recently published trials also indicated that lifestyle modification and various pharmacological agents can delay or prevent the development of glucose disturbances to overt diabetes.
There are several factors contributing to this deficiency state among them behavioral factors, for example limited sun exposure or malnutrition, which can be partially altered by behavior modification and various intrinsic factors like reduced synthetic capacity.
The original paper [1] was followed by a flurry of activity, e.g., improved analyses [2]-[7], code modifications [8]-[10], decoder modifications [11]-[14] [11]-[14]ous generandzations [15]-[18].
Post-translation histone modifications and the various combinations thereof have been proposed to "write" the "histone code" creating extensive diversity through such combinatorial sets of modifications for the recruitment of distinct regulatory proteins and complexes [24].
Given the abundance of cellular post-translational modifications, and their various effects on the structures and functions of disordered proteins (see section 3.6), paired with the unique ability of NMR spectroscopy to detect PTMs and their structural consequences, in-cell NMR methods are well-suited to report on the in vivo characteristics of IDPs in a fully integrated manner.
Several studies have indicated that the mechanism of the allelic-specific expression could be regulated by epigenetic modification, including DNA methylation and various histone modifications [ 52, 53].
Among their translation products are nucleoid-associated proteins, cell envelope proteins, response regulators, enzymes involved in posttranslational modification and in various metabolic functions, and uncharacterized proteins.
Behavioural modification is gradual, and various behavioural effects arise in a consistent order.
Chromatin may thus generate autoimmunity by quite different pathways linked to modification of chromatin and various infections [ 36, 72].
