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They have made possible wholesale scans that turn up new gene modifications and variations, and the same should prove true for the new human gene arrays, says Joseph Ecker, a plant scientist at the Salk Institute for Biological Studies in La Jolla, California, who has helped pioneer whole-genome chips for Arabidopsis.
Several modifications and variations have been developed to maximize the benefits of treatment while minimizing adverse events [ 19, 23, 24].
The most common epigenetic modifications (Fig. 1) are changes in the DNA methylation pattern, posttranslational histone modifications, and variations in the expression of non-coding microRNA (miRNA).
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It was shown through modification and variations of the calcite precipitation treatment that differences in the calcite fill would occur but all methods were successful in partially blocking the different porous media.
No single formula is applicable to all tropical situations, but with infinite modification and variation certain principles can be widely adapted to tropical housing problems.
Modifications and size variations have been reported during miRNA maturation in different organisms [ 19- 24].
Specifically, our results show that chromatin accessibility, histone modifications, and genetic variations in peak regions can explain some of the cell-type specific peaks.
Monozygotic twins display significant life course variation in epigenetic modifications, and this variation, it is thought, may drive disease pathogenesis [ 60].
On the other hand, the interaction between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical properties of nucleobases.
Nowadays, various environmental factors have been considered to contribute to genetic and epigenetic modifications and influence phenotypic variations.
A limitation of the tagSNP approach used here is that it does not address the impact of less common or rare variants (MAF < 5 %), SNPs not in LD with typed variants, insertions/deletions, epigenetic modifications, and copy number variations, on treatment response.
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