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The generation of transgenic plants bearing resistance to multiple xenobiotics can easily require several genetic modifications, and thus the identification of single genes conferring Multiple Drug Resistance (MDR) in plant systems is highly desirable.
On the other hand, the interaction between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical properties of nucleobases.
Because enzymes responsible for adding or removing epigenetic marks are dependent upon, or influenced by, metabolites, metabolic flux is now recognised as an important driver of DNA and histone modifications and thus a prime mover in gene regulation24,25,40 (Fig. 1).
The investigated treatments offer numerous advantages over previous physical/chemical modifications and thus are expected to expand the utility of chitosan fibers with tunable mechanical properties in various tissue engineering applications.
The chemistry of gold nanoparticles (AuNPs) facilitates surface modifications and thus these bioengineered NPs have been investigated as a means of delivering a variety of therapeutic cargos to treat cancer.
The latter factors also include those that cause environmental impacts and modifications and thus have implications for the structure and functioning of individuals, populations and communities within ecosystems.
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First, consumers fail to appreciate the risk of unilateral modification and thus fail to demand a commitment by sellers to avoid inefficient modifications.
The abundant surface groups (mainly OH) on Ti3C2Tx allowed facile modification, and thus evenly functionalized nanosheets were obtained.
However, the donor T cells used in human ACT trials often receive stimulations during ex vivo expansion or genetic modification, and thus are mostly activated T cells at the time of infusion.
It is a "germ-line modification", and thus irrevocable.This ethical objection to mitochondrial donation is decisively outweighed by the good that ought to come from it.
In addition, the simple "mix and measure" assay can be extended to detect other types of targets upon slight modification, and thus provides a tool for the early diagnosis and risk assessment of malignancy.
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