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Modifications and substitutions are often made for reasons of economy and convenience.
The most frequent replacements for self-bioisosteres are the following: halogen replacements (nearly 50%% of all substitutions), ring modifications, and substitutions.
In different organisms, the maintenance of alternative structural and functional chromatin states is regulated in part by chromatin modifications that are both physically associated with and inherited with the chromosome on which they act, including DNA methylation, histone modifications and substitutions, nonhistone chromatin proteins, and noncoding RNAs (Bonasio et al. 2010).
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For variants containing terminal modifications and internal substitutions, the NCBI Blastn program was used to compare all qualified sequence reads with identified miRNAs.
Various studies have assessed BiVO4 modifications [20, 22 24], and substitution or metal doping on BiVO4 has been shown as the most efficient method to change its carrier transport efficiency.
Regarding the role of the phenyl substituent to obtain selective ligands, modulation of selectivity and activity have been achieved by modifications of the acyl group and substitutions on the phenyl ring.
The main feature of synthesized and natural mercury chalcogenhalogenides is the formation of numerous polymorphic modifications and existence of isomorphic substitutions in chalcogen and halogen anion sublattices.
The differences between the obtained sequences the authors interchangeably call "polymorphisms", "substitutions", "modifications" and "mutations".
The search parameters included aminocarbamidomethyl cysteine, all biological modifications and amino acid (AA) substitutions, and one missed trypsin cleavage.
Although, regulation effects are not so widely applied in genome modification as disruption and substitution.
The triterpenoid backbone then undergoes various modifications (oxidation, substitution and glycosylation) mediated by cytochrome P450-dependent monooxygenases, glycosyltransferases and other enzymes [ 14].
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