One of them is the human control, modification and replication of whole ecosystems.
These complexes explain the critical role for Rik1 and how multiple processes of transcription, chromatin modification and replication are intertwined.
Most of the cracks detected by this criterion were related to DNA modification and replication (data not shown).
In particular, some of the identified proteins (SUMO1, FYN, and NEDD8) were found to be involved in the HIV-1 covalent modification and replication 44, 45 and HIV-associated lipodystrophy.
Bioinformatic analyses enabled the assignment of putative functions to 36 and 29 gene products, respectively, including DNA packaging and morphogenetic proteins, lysis components, and proteins necessary for DNA recombination, regulation, modification and replication.
There is currently more data to support the hypothesis that intragenic DNA methylation is a consequence of other mechanisms of transcriptional regulation, including histone modifications, nucleosome positioning and replication timing.
Thus, the ORC-associated Hat1p-dependent histone acetyltransferase activity suggests a novel linkage between histone modification and DNA replication.
Moreover, whether drifts in regulatory states occur depends also on the ratio of time scales, for example, of histone modification and cell replication.
40 We considered three major COGs/KOGs 40 categories involved in protective functions by comparison of our tardigrade data and protein clusters to the other two organisms regarding the COGs/KOGs categories V (defence mechanisms), O (posttranslational modification) and L (replication, recombination and repair).
Although the exact function of HMGN3a during early embryonic development has not been determined, its role in facilitating chromatin modifications and enhancing transcription, replication, and DNA repair is critical for early embryo development [ 8].
