Sentence examples for modifications and regulatory from inspiring English sources

This suggests that high levels of H3-K27me3 may lock in the repressed state of Sox1 in NS cells while lower levels may still allow its up-regulation at day 8, confirming that the H3-K27me3 status contributes to transcriptional output only in the context of other histone modifications and regulatory inputs.

Metazoan gene expression is controlled through the complex interplay of transcription factors, histone modifications and regulatory elements [ 1, 2] in three-dimensional nuclear space [ 3].

The acceleration of expression divergence is probably driven by functional redundancy created by the first round of whole genome duplication and facilitated by epigenetic modifications and regulatory mutations.

These epigenetic influences include DNA methylation, post-translational histone modifications and regulatory noncoding RNAs, all of which can have profound effects on gene expression that control cell phenotype and function [ 48].

84 These types of SIRT1 activity regulations (both posttranslational modifications and regulatory complex formation) have not been thoroughly explored in skeletal muscle, making it an important direction for future research.

Since transcriptomics data do not necessarily reflect enzyme activities (due to post-transcriptional modification and regulatory effects), we use the results from the analysis of the expression data only as indicator for the activity of the respective reaction rather that definite values.

This may be a complex network of positive and negative regulatory loops, operating through transcription factor networks, epigenetic (DNA and chromatin) modifications, and miRNA regulatory networks.

The multivariate model using DNA methylation, eight histone modifications, and two regulatory protein complexes (CTCF and cohesin) as predictors has better performance (accuracy = 95.1%) than any univariate models of single predictors.

Our results give insight into the connections between chromatin modifications and transcriptional regulatory activity and provide a new tool for the functional annotation of the human genome.

We conclude that yeast can be used as a model organism to study p53 post-translational modifications and their regulatory effects on p53 function and localization.

The condensation level of chromatin is controlled by epigenetic modifications and associated regulatory factors and changes throughout differentiation and cell cycle progression.