Although many studies have found that CRISPR/Cas9 technology is more efficient, specific and manipulable than previous generations of gene editing tools, it can be further improved by elevating its overall efficiency in a higher frequency of genome modifications and reducing its off-target effects.
(A) The amount of GTP-bound Rac1 was increased by the ubiquitin modification, and reduced by the NS1 protein expression.
Resistance to antibiotics occurs classically as a result of drug modification, target alteration, and reduced accumulation owing to decreased permeability and/or increased efflux.
The reported increase in prescription of bDMARDS by patients' medical practitioner should be viewed as a positive and essential adjunctive strategy for disease modification and reducing impairment and disability.
Its composition is closely related to issues such as direct and indirect climate modifications, air pollution, and reduced visibility.
ER stress causes a decrease in SEAP activity not via transcriptional suppression but via abnormal posttranslational modification, accelerated degradation, and reduced secretion of SEAP protein.
Altered expression of multiple factors results in capillary and arteriole rarefaction in limbs and heart modifications and a reduced post-ischaemic angiogenic and collateral vessel formation.
The initial item pool with 102 items had been tested with 15 adolescents, leading to some modifications and a reduced pilot version with 96 items (e.g. leaving out the items about sexual development because of high missing rates or negative feedback of the adolescents).
The survey was piloted for approximately 1 month and after minor modifications, for instruction clarity and reduced length, distributed via email to attending physicians, nurse practitioners and residents training in the fields of internal medicine (IM) and emergency medicine (EM).
