Recent studies on miRNA profiling performed with cloning suggest that sequencing is useful for the detection of novel miRNAs, modifications, and precise compositions and that miRNA expression levels calculated by clone count are reproducible.
Moreover, recent studies on miRNA profiling performed with cloning techniques suggest that sequencing methods are suitable for the detection of novel miRNAs, modifications, and precise compositions, and that cloning frequencies calculated by clone count analysis strongly correlate with the concentrations measured by Northern blotting, and are reproducible.
The biomacromolecule DNA has the characteristics of highly specific, predictable and thermoreversible base-pair interactions with its complementary DNA strand, easy chemical synthesis and modification, and precise sequence manipulation.
Having a well-defined molecular structure, fMLF offers an opportunity for chemical modifications and for precise control and accurate understanding of immunomodulation at the molecular level.
Genetic modification comprises the controlled and precise modification of an organism's genome using recombinant DNA and other molecular techniques, in order to alter a trait of interest.
Modifications are targeted and precise and can range from single base-pair deletions or insertions to the addition or deletion of sequences in the kilobase-pair range.
Despite of well-known advantages of high molecular weight polyethylene (Medpor, Synpore) in orbital reconstructions, the thickness of those implants significantly exceeds 0.5 mm and precise modification of thickness is limited.
Because most first-breeding females in the recently-established Montana population are long-distance immigrants from southern populations [ 24], they are not expected to have either an evolved recognition of the local environmental stimulus at the northernmost part of the species' range or an evolved and precise modification of ovulation sequence in response to this stimulus.
MS offers an unbiased approach to mapping the combinations of histone modifications and requires highly sensitive and precise mass measurements; for example, the difference in mass between trimethylation and acetylation is only 36 mDa.
More precise modifications, and better technologies for monitoring stray DNA both within plants and in the environment around them, mean that it is getting easier to be sure that nothing untoward is going on.Then there is the worry that GM crops are a way for big companies to take over the livelihoods of small farmers and, in the end, a chunk of nature itself.
More recently, the emergence of genome editing technologies enabling direct and precise genome modification have allowed gene replacement or target-specific gene insertion via homologous recombination, and site-specific gene deletion or insertion via non-homologous end joining on the target of interest by using custom engineered nucleases15.
