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Knowledge about heterochromatin, histone modifications, and nuclear architecture will help our understanding of epigenetic mechanisms that control gene function at traits related to vectorial capacity.
Here, we discuss recent advancements contributing to our understanding of the mechanisms controlling gene regulation in the parasite, including nucleosome landscape, histone modifications, and nuclear architecture.
In particular, we are beginning to understand how universal mechanisms of chromatin modifications and nuclear position effects are deployed for parasite-specific functions and are centrally involved in genomic organisation and transcriptional regulation.
The epigenetic layers, such as DNA methylation, histone modifications and nuclear architecture are now being extensively studied in many cell types and disease settings.
Thus, the morphological variability, directional modifications, and nuclear chromatin condensation were examined by different techniques such as fluorescent microscopy and SEM.
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He spent an unusually long time – six years – as a junior minister in the same post, and gradually grew tired of ministers, departmental officials and advisory panels undermining true environmental policies, as Blair's No 10 interfered over policies on genetic modification and nuclear energy, on which he was extremely sceptical.
Heat stress activates the conserved transcription factor heat-shock factor-1 (HSF-1) via a multistep process involving oligomerization, post-translational modification, and nuclear translocation.
The sumoylated and unsumoylated RanGAP-1 protein also interacts with Tollip, suggesting a possible role in RanGAP-1 modification and nuclear-cytoplasmic protein translocation.
Recent studies have demonstrated that lncRNAs regulate many processes such as transcription, translation, cellular differentiation, gene expression regulation, cell cycle regulation, chromatin modification, and nuclear-cytoplasmic trafficking [ 20, 26– 28].
Recent studies have demonstrated that lncRNAs regulated several biological processes such as transcription, translation, cellular differentiation, gene expression regulation, cell cycle regulation, chromatin modification, and nuclear-cytoplasmic trafficking [ 13– 15].
By inducing RNA-chromatin binding a number of RNA-dependent activities can be dissected: (i) The RNA-induced compaction or decondensation of chromatin, (ii) identification of RNA-interacting chromatin modifiers that set epigenetic signals such as posttranslational histone modifications, and (iii) nuclear relocation of a genomic locus targeted by the tethered RNA.
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