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Epigenetics comprises the combined action of DNA methylation, histone modifications, and noncoding RNAs.
Epigenetic perturbations, such as in DNA methylation, histone modifications, and noncoding RNA, are commonplace during the development and progression of lung cancer.
This review summarizes our current knowledge on the effects of environmental chemicals on DNA methylation, histone modifications and noncoding RNAs in the context of DOHaD, and suggest some key considerations in designing experiments for characterizating the mechanisms of action.
Key epigenetic events, such as DNA methylation, histone modifications, and noncoding RNAs, play important roles for normal development and cell differentiation and serve as mechanism of genomic adaption to various environmental stimuli including those that adversely impact human health.
The integration of genetic and environmental signals required for regulating brain development and function is achieved in part by a dynamic epigenetic landscape that includes DNA methylation, histone modifications, and noncoding RNAs.
36 Epigenetic modifications (DNA methylation, histone modifications and noncoding RNAs) have a fundamental role in the regulation of gene expression.
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The most important ones are DNA methylation, histone modification, and noncoding RNAs, most of which is known from animal and cell culture studies [7].
These pathways, as currently understood, include DNA methylation, histone covalent modification, and noncoding RNA expression.
Major forms of these changes are DNA methylation, histone modification, and noncoding RNAs (ncRNAs) (Rivera and Bennett 2010).
Additional regulatory mechanisms, involving DNA methylation, histone modification and noncoding RNAs, are likely to contribute to these processes.
Epigenetic mechanisms (e.g., DNA methylation, chromatin modification, and noncoding RNAs) have been suggested to regulate the OA-specific genes responsible for cartilage degradation (Hashimoto et al., 2009).
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