The data from single metabolite measurements were normalized to the "day 0 sample" of each treatment and sample modification, in order to depict the variability from storage over time on the abscissa, while variability from sample modification and multiple measures is depicted as standard deviation (SD).
Both RING -and HECT-type ubiquitin ligases undergo various modifications and have multiple mechanisms that act to stabilize and/or activate these dynamic enzymes.
Their letter criticizes the banks for "unanswered phone calls, delays in the modification process and multiple requests for homeowners to resend paperwork already submitted".
Sensing through intracellular metabolites acting as second or 'metabolic messengers' is obviously difficult to study because it requires the technical possibility of carrying out precise genetic modifications at single and multiple reactions in metabolic pathways, as well as the determination of all relevant metabolic intermediates.
UBE2D1 and UBE2D3 work with most E3 ligases, are non-specific for substrate modification and assemble multiple linkage types in vitro (Kim et al, 2007; Dynek et al, 2010).
Choice of footwear modification was left to the shoe technician, and multiple modifications were allowed within one round.
Accordingly, we developed a manually curated resource entitled 'EpimiR' (http://bioinfo.hrbmu.edu.cn/EpimiR/), which provided a comprehensive repertory of experimentally validated interactions between epigenetic modifications and miRNAs across multiple species and filled the vacancy in this field.
This paper focus on the structural modal reanalysis for large and multiple modifications (including simultaneous boundary, topology and type modifications), which can greatly affect the eigen-modes of the modified structures.
SUMO modification usually is reversible, and multiple SUMO-specific proteases that remove the modification have been identified [5], [6].
Hawkins, Patterson, and their husbands, in connection with each loan (and multiple modifications of each loan), executed personal guaranties in favor of Raymore.
