The team says it's the first to establish a specific link between aberrant histone modification and mechanisms underlying lupus-like symptoms in mice, and they confirmed that a drug in the research stage, trichostatin A, could reverse the modifications.
It has been suggested that post-translational modification may be responsible to unmask the HJ resolvase activity in GEN1 (Ip et al. 2008), but the nature of the modification and mechanisms involved have not been determined yet.
Recent studies have confirmed that RNA editing [36], [37] and non-template extension [26] are common post-transcriptional modifications, and these mechanisms could account for the wide diversity of sequence variations observed in mature EBV miRNA.
But protein interactions are regulated dynamically, through post-translational modifications and other mechanisms, suggesting that the specificity of DNA binding transcription factors like c-Myb, and the set of target genes that it binds to, could change rapidly in a time-dependent manner.
These studies highlighted enriched functions (transcription, RNA post transcriptional modifications) and molecular mechanisms (cell cycle, androgen signaling) in human oocytes, which were also identified in the only preliminary analysis conducted in sheep species to date [ 12].
Among the newly detected versions in this study we found several conserved gene neighborhood associations for AlbC-like CDPSs that might be indicative of alternative modifications and synthetic mechanisms for the dipeptides generated by them.
However, we additionally report for the first time that this vasodilator response (Fig. 2b), and the expression and function of VSM SERCA and PMCA (Figs. 3 and 4), are altered with time on high fat diet and reveal modifications and compensatory mechanisms of Ca2+ handling in the disease state (Fig. 5).
This paper reviews recent progress in the design of novel Mg alloys, surface modification and corrosion mechanisms under different conditions, and describes the effects of the structure, composition, and surface conditions on the degradation behavior in vitro and in vivo.
Discussed below are the unique combinations of import, chaperone, modification, and export mechanisms involved in metal homeostasis and toxic metal resistance in eight sequenced Frankia strains.
