Emerging evidence shows a relationship between physiological stress, changes in carbon metabolism and protein modifications, and a key role for sirtuins in maintaining metabolic homeostasis.
The Pentagon says that an "active" stock of warheads should be maintained which would incorporate the latest modifications and have the key parts.
Among the six or seven of us, we all had the staple elements — Swiss Army knife, wrist rocket, eye black, as many bandannas as possible — so the equipment modifications and additions became key.
These processes are regulated by transcription, translation, post-translational modifications and degradation of key regulatory proteins, and as such, the ubiquitin proteasome system has a crucial role in maintaining and regulating cellular homeostasis [7].
Histone modification H4K20me3 is a known repressive mark [ 13], and key modification regulating compaction of the chromatin in pericentric regions, which makes it crucial for proper chromosome segregation during cell division and for maintenance of genome integrity [ 12].
In 1958, Daniel Koshland suggested a modification to the lock and key model: since enzymes are rather flexible structures, the active site is continuously reshaped by interactions with the substrate as the substrate interacts with the enzyme.
This study explores whether there is any effect modification between lead exposure and key sociodemographic factors on IQ [measured using the Wechsler Intelligence Scales for Children-Revised (WISC-R) instrument] at 11 13 years of age.
Thus, characterizing global nucleosome positions and their chemical and compositional modifications is key to unravelling the mechanism of transcriptional regulation.
This is because molecular binding is the paramount factor in such ligand cellular system and key structural modifications around ligand binding are expected to create outliers.
The present discoveries of carotenoid-related biological processes also support previous studies of carotenoid-associatied plastid development and key metabolic modifications [ 14, 22, 23].
