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The display of the data in the molecule pages is new to many reviewers, particularly in the States and Transitions sections, where covalent modifications and interactions with binding partners are broken down and represented systematically.
Although microarrays for transcriptome can be used to detect gene expression in organs, it is the array of proteins that are found within the cell, together with their modifications and interactions, which hold the key to understanding of biological systems.
Activation of the GLI proteins is an intricate process that involves modifications and interactions of a number of positive and negative pathway regulators and is not fully understood [1], [14], [35].
Interestingly, it possesses only one (N-terminal) of the two nuclear localization signals that are seen in other mammalian poly(A) polymerases, and lacks the C-terminal domain that is involved in various regulatory modifications and interactions.
Receptor function is further modulated by post-translational modifications and interactions with other nuclear proteins.
The purpose of an extended contact map is to provide a high-level understandable illustration of the material components, post-translational modifications, and interactions included in a model.
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Mass spectrometry-based proteomics techniques facilitate the characterization of the protein profile of a sample7, via qualitative and quantitative measurements, and assessments of posttranslational modifications and interaction of proteins8.
The specificity of CKα antiserum also makes it suitable for immunoprecipitation of total CKα from cell extract to study the in vivo properties of this isoform in terms of post-translational modifications and interaction with other CK isoforms [23] or proteins.
In addition, the regulation of HOX expression is significantly correlated with histone modifications and interaction with Polycomb group genes [ 47, 48].
Given the complex regulation of PGC1α function by post-translational modifications and interaction with other binding proteins, further experiments are needed to confirm this hypothesis.
Table 2 summarizes the effects of modification and interactions of the Cu2+ with the raw and modified biomas.
More suggestions(15)
change and interactions
modifications and between
modifications and refinements
modifications and manufacturers
modifications and prospects
modifications and medications
modifications and generalizations
modifications and substitutions
modifications and safeguards
modifications and foreclosures
modifications and facelifts
modifications and improvements
modifications and inspections
modifications and adaptations
modifications and mutilations
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