Sentence examples for modifications and editing from inspiring English sources
Interesting questions remain both for understanding the effects of modifications and editing on microRNAs and the interactions between microRNAs and other cellular RNAs such as long noncoding RNAs.
No alteration in the editing reaction was observed after celecoxib treatment, indicating that editing levels are extremely conserved and editing modifications may occur only after a longer treatment or in a situation of life-time inhibition of COX-2 activity as observed in COX-2−/− mice.
Non-coding RNA (ncRNA) or small RNA (sRNA) genes, which encode functional RNA molecules that are not translated into proteins, are involved in a variety of cellular processes ranging from regulation of gene expression to RNA modification and editing (Gottesman, 2005; Huttenhofer et al., 2002).
Permitted modifications consist of changing the energy coupling, editing the protein annotation and editing the reaction (including the primary substrate and compartment assignments).
Taking advantage of ΦC31 attP sites, gene trap cassettes in MiMIC can be easily swapped with any DNA sequence flanked with attB sites by ΦC31 recombinase, allowing further gene modifications and genome editing [ 33].
Recent literature on RNA sequencing highlights several posttranscriptional modifications and RNA editing in many organisms, including M. oryzae, resulting in imperfect alignment of RNAs to the reference genome [ 25, 30].
DOI: http://dx.doi.org/10.7554/eLife.05198.013 10.7554/eLiFigure98.014 figure 4—figure supplement 2. The fraction of nonsynonymous codon changes as a function of editing levels and the amino acid modifications due to editing.
The combinatorial utilization of flexible epigenomic modifications, together with gene splicing, post-translation protein modification and RNA editing has ample potential to generate functional diversity from a fixed genotype.
While technological advancements have enabled research into genetic modifications, removing or editing human genomic sequences has unknown consequences.
A considerable number of modifications (A to I editing and 2'-O-methylation of ribose,) are known to exist in plant miRNA [ 18].
