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Table 5-wrap> shows the DLTs, dose modifications and delays in treatment.
Feasibility: will be measured through the number of protocol dose modifications and delays.
Activity will be measured as treatment failure-free rate and feasibility as the number of protocol dose modifications and delays.
Dose modifications and delays were permitted as follows: an ANC <1000 cells μl−1 or a platelet count <75 000 cells μl−1 by day 1 of the subsequent cycle necessitated a 1 week treatment delay.
Chemotherapy dose modifications and delays of BCNU and MTX are summarized in table 3. The median RDI for BCNU and MTX were 0.98 (0.31-1.1) and 0.96 (0.57-1.66) respectively.
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Dose modification and delay was permitted in the event of some treatment-related side effects.
As it is to be expected from any large conference the program suffered quite a few last-minute modifications and notable delays, which prevented me from attending two of the talks I was looking forward to the most, the one by Bernardo Hernández (@BernieHernie) and the one by Martín Varsavsky (@Martinvars), which no doubt I will be watching as soon as their recordings are made available.
Intracycle and intercycle dose modifications and course delays for S-1 were used.
The combination also had increased toxicity resulting in more dose reductions, modifications, and treatment delays.
Cycle 1 and 2 dosing histories (dose modifications and dose delays) were required to simulate week 6 tumor shrinkage using the TGI model.
Also, we compared rates of dose modification (reductions and delays) in the first 12 weeks of treatment.
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