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Furthermore, our mouse model can also be used to directly and specifically isolate CM nuclei for the analysis of epigenetic chromatin modifications, an approach recently established in CMs [ 13].
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With the progress in molecular biology it has become possible to optimize industrial fermentations through introduction of directed genetic modification – an approach referred to as metabolic engineering.
"Genetic modification is an approach, a tool," he says.
This analysis is a modification of an approach used by Oldham and colleagues to examine coexpression networks in human and chimpanzee brains [11].
DNA fragments were prepared by slight modification of an approach described before [ 24].
However, as the optimal configuration may contain a combination of different modifications a systematic approach is necessary to consider all possibilities.
This method allows the selectable marker gene to be recycled for multiple modifications, a useful approach for other genetic manipulations in the yeasts.
Dietary modification may be an approach to reducing CKD.
Despite this recommendation, our review of the literature revealed only one study that targeted lifestyle modification (diet) as an approach for improving glycemic control in this population.
Improving risk factor modification: a global approach.
Consistent with the proposed susceptibility of BiP to glutathione modification, a proteomics approach previously identified mammalian BiP (and 22 additional proteins) as a substrate for glutathiolation during diamide-induced oxidative stress in endothelial cells (Lind et al., 2002).
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