Managers cannot simply declare, "Let's raise prices to increase the value of our project". More likely, they will invent and evaluate complex proposal modifications driven or constrained by technology, demographics, regulations, and so on.
By comparing the metabolomes, transcriptomes and epigenomes of human pluripotent stem cell lines, Sperber et al. show that interplay between the metabolome and histone modifications drives the metabolic switch from naive to primed pluripotency.
In tropical dry forest systems (Janzen 1988), grass intrusion and other habitat modifications driven by anthropogenic disturbance can yield widely different outcomes depending on the degree of degradation and frequency of perturbation.
We aim to show that long synfire chains emerge in a network of spontaneously spiking neurons, through connectivity modifications driven by Hebbian synaptic plasticity and axon remodeling when a subset of them are activated intermittently by external inputs.
The combinatorial binding of cell-type-specifying transcription factors (TFs) and epigenetic modifications drives this enhancer activity.
Therefore, it is possible that a specific post-translational modification drives conformational changes which subsequently expose this buried NES sequences for p68 export [ 55].
While it is likely that chromatin modifications such as acetylation and deacetylation play roles in regulating the mechanical properties of chromatin fibers during segregation [ 46], the evidence that these modifications drive the formation of mitotic chromosomes remains limited.
Polyubiquitin (polyUb) modifications drive the destruction of a majority of cellular proteins by targeting them either to the lysosome or to a 2.5 MDa multi-catalytic protease, the 26S proteasome [ 2– 4].
Expression levels of Bcl-2 family proteins are altered, or they are targeted by a myriad of post-translational modifications driven by oncogenic signaling pathways, with an increase of anti-apoptotic or a decrease of pro-apoptotic functions.
The epigenetic modifications, driven by specific enzymes such as DNA methyltransfereases (DNMTs) and histone remodeling enzymes (Jarid, SIRT1 and others), dynamically interact with each other to define the correct transcriptomic profile.
O-GlcNAc modification is driven by the glucose concentration and has a profound effect on Sp1 activity.
