We recognize that additional modification or formulation of the plant-produced enzyme might be necessary or desirable prior to adoption for human use and that such additional modifications would increase the cost of the AI.
Our method could be improved in several ways, such as by modeling mutations or LD between markers, and using haplotypes with more than two markers, but it is unclear whether these modifications would increase the precision.
Glu47 is also a candidate for gamma carboxylation [14], a post-translational modification that would increase its capability of coordinating Ca2+.
They include adjacent DNA elements and/or post-translational modifications of E2F protein, which may increase binding affinity, as well as chromatin modifications that would increase accessibility to the DNA and E2F interactions with other transcription factors, which allow the formation of more stable, cooperative multimeric complexes [8].
Nevertheless, because our goal was to utilize modifications that would increase hybridization signals for the vast majority of target-probe duplexes, we subsequently focused our efforts on the samples containing DAP. MeC and MeU substitution increases signal intensities for a small number of probes.
But his hopes were dashed when it turned out that the proposed modification would actually increase his monthly payment by $500.
Operating expenses have not been affected by buyers who have not signed up for Internet service, and Netpliance's modification would not increase i-Opener production costs, the company said.
Lowering the p Ka of tyrosines in albumin by modifying their environment, either by mutagenesis or by chemical modification of vicinal residues, would increase the reactivity of albumin with OP. Specific nitration of tyrosine by tetranitromethane was found to lower the p Ka of tyrosine to 6.8 (20).
To assess whether modifications of the algorithm would increase the PPV without decreasing the sensitivity, additional analyses were performed.
